The α-defensins from Paneth cells in intestinal crypts need processing to be fully functional. Unlike for mice, the cleaving enzyme for human HD5 turns out to be trypsin.
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Zasloff, M. Trypsin, for the defense. Nat Immunol 3, 508–510 (2002). https://doi.org/10.1038/ni0602-508
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DOI: https://doi.org/10.1038/ni0602-508
