Although cytokines and STATs are accepted as being integral to TH1 differentiation, T-bet had emerged as a possible master control switch. Fresh data forces a reexamination of the factors that control TH cell development.
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O'Shea, J., Paul, W. Regulation of THI differentiation – controlling the controllers. Nat Immunol 3, 506–508 (2002). https://doi.org/10.1038/ni0602-506
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DOI: https://doi.org/10.1038/ni0602-506
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