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CD3ɛ: PeRuSing for positive selection

Nature Immunology volume 9, pages 457–459 (2008)Cite this article

How engagement of surface T cell antigen receptors 'translates' into intracellular signal cascades remains vague. Genetic and biochemical experiments now allow modification of a model linking ligation of these receptors with CD3ɛ and other cytoplasmic signal-transduction 'machinery'.

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Figure 1: The function of the CD3ɛ PRS in the absence of TCR-pMHC interaction.

Kim Caesar

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Authors and Affiliations

  1. Jonathan S. Maltzman is in the Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA. maltz@mail.med.upenn.edu,

    Jonathan S Maltzman

  2. Gary A. Koretzky is in the Department of Pathology and Laboratory Medicine, the Department of Medicine and the Abramson Family Cancer Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA. koretzky@mail.med.upenn.edu,

    Gary A Koretzky

Authors
  1. Jonathan S Maltzman
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  2. Gary A Koretzky
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Maltzman, J., Koretzky, G. CD3ɛ: PeRuSing for positive selection. Nat Immunol 9, 457–459 (2008). https://doi.org/10.1038/ni0508-457

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