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TRIM-ing down Tolls

Nature Immunology volume 9, pages 348–350 (2008)Cite this article

Activation of the transcription factor NF-κB by Toll-like receptors must be controlled to avoid excessive inflammation. The tripartite-motif protein family member TRIM30α has now been shown to mediate a negative regulatory feedback mechanism curtailing such responses.

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Figure 1: TRIM30α negatively regulates TLR4 signaling.

Kim Caesar

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  1. Andrew G. Bowie is with the School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland. agbowie@tcd.ie,

    Andrew G Bowie

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  1. Andrew G Bowie
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Bowie, A. TRIM-ing down Tolls. Nat Immunol 9, 348–350 (2008). https://doi.org/10.1038/ni0408-348

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