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Deciding the decider: Mef2c in hematopoiesis

Factors influencing progenitor cell 'choice' between lymphoid and myeloid lineage fates are incompletely understood. New work implicates the transcription factor Mef2c as one component needed to promote lymphoid and suppress myeloid lineage differentiation.

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Figure 1: The Mef2c regulatory circuit and the main cell fates it directs.

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Gerstein, R. Deciding the decider: Mef2c in hematopoiesis. Nat Immunol 10, 235–236 (2009). https://doi.org/10.1038/ni0309-235

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