The intrinsic stability of mRNA is important in the regulation of gene expression. New data show that the intrinsic stability of tumor necrosis factor–induced mRNA transcripts strongly influences the coordinated expression of genes that promote distinct phases of the inflammatory response.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
MAPKAPK2: the master regulator of RNA-binding proteins modulates transcript stability and tumor progression
Journal of Experimental & Clinical Cancer Research Open Access 08 March 2019
-
Aqueous extracts from dietary supplements influence the production of inflammatory cytokines in immortalized and primary T lymphocytes
BMC Complementary and Alternative Medicine Open Access 14 December 2009
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Hao, S & Baltimore, D. Nat. Immunol. 10, 281–288 (2007).
Chin, A.C. & Parkos, C.A. Annu. Rev. Pathol. 2, 111–143 (2007).
Bradley, J.R. J. Pathol. 214, 149–160 (2008).
Kontoyiannis, D., Pasparakis, M., Pizarro, T.T., Cominelli, F. & Kollias, G. Immunity 10, 387–398 (1999).
Feldmann, M. Annu. Rev. Immunol. (in the press).
Beg, A.A. & Baltimore, D. Science 274, 782–784 (1996).
Hoffmann, A., Leung, T.H. & Baltimore, D. EMBO J. 22, 5530–5539 (2003).
Stoecklin, G. & Anderson, P. Adv. Immunol. 89, 1–37 (2006).
Carballo, E., Lai, W.S. & Blackshear, P.J. Science 281, 1001–1005 (1998).
Fenger-Gron, M., Fillman, C., Norrild, B. & Lykke-Andersen, J. Mol. Cell 20, 905–915 (2005).
Stoecklin, G. et al. EMBO J. 23, 1313–1324 (2004).
Taylor, G.A. et al. Immunity 4, 445–454 (1996).
Keene, J.D. & Lager, P.J. Chromosome Res. 13, 327–337 (2005).
Stoecklin, G. et al. J. Biol. Chem. 283, 11689–11699 (2008).
Anderson, P. Nat. Immunol. 9, 353–359 (2008).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Anderson, P. Intrinsic mRNA stability helps compose the inflammatory symphony. Nat Immunol 10, 233–234 (2009). https://doi.org/10.1038/ni0309-233
Issue Date:
DOI: https://doi.org/10.1038/ni0309-233
This article is cited by
-
MAPKAPK2: the master regulator of RNA-binding proteins modulates transcript stability and tumor progression
Journal of Experimental & Clinical Cancer Research (2019)
-
Post-transcriptional regulons coordinate the initiation and resolution of inflammation
Nature Reviews Immunology (2010)
-
Aqueous extracts from dietary supplements influence the production of inflammatory cytokines in immortalized and primary T lymphocytes
BMC Complementary and Alternative Medicine (2009)