Although the development of natural killer T cells is a T cell antigen receptor–dependent process, the signaling pathways involved are poorly defined. New data demonstrate that the calcineurin–transcription factor NFAT pathway exerts a critical influence on this process by controlling the transcription factor Egr2.
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Godfrey, D., Stankovic, S. & Baxter, A. Developing NKT cells need their calcium. Nat Immunol 10, 231–233 (2009). https://doi.org/10.1038/ni0309-231
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DOI: https://doi.org/10.1038/ni0309-231
