'Promiscuous' gene expression in medullary thymic epithelial cells positive for the autoimmune regulator Aire is critical for central T cell tolerance. Expression of the tight-junction components claudin-3 and claudin-4 'marks' Aire+ epithelial cells in the postnatal thymus and their direct precursors in the embryo.
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Katie Ris
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Holländer, G. Claudins provide a breath of fresh Aire. Nat Immunol 8, 234–236 (2007). https://doi.org/10.1038/ni0307-234
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DOI: https://doi.org/10.1038/ni0307-234
