The signaling adaptor Act1 is now shown in vivo to be essential for interleukin 17–mediated inflammation in the brain during experimental autoimmune encephalomyelitis and in gut epithelial cells during induced colitis.
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References
Qian, Y. et al. Nat. Immunol. 8, 247–256 (2007).
Schwandner, R., Yamaguchi, K. & Cao, Z. J. Exp. Med. 191, 1233–1240 (2000).
Novatchkova, M., Leibbrandt, A., Werzowa, J., Neubuser, A. & Eisenhaber, F. Trends Biochem. Sci. 28, 226–229 (2003).
Li, X. et al. Proc. Natl. Acad. Sci. USA 97, 10489–10493 (2000).
Leonardi, A., Chariot, A., Claudio, E., Cunningham, K. & Siebenlist, U. Proc. Natl. Acad. Sci. USA 97, 10494–10499 (2000).
Chang, S.H., Park, H. & Dong, C. J. Biol. Chem. 281, 35603–35607 (2006).
Qian, Y. et al. Immunity 21, 575–587 (2004).
Qian, Y., Zhao, Z., Jiang, Z. & Li, X. Proc. Natl. Acad. Sci. USA 99, 9386–9391 (2002).
Hunter, C.A. Nat. Rev. Immunol. 5, 521–531 (2005).
Langrish, C.L. et al. Immunol. Rev. 202, 96–105 (2004).
Langowski, J.L. et al. Nature 442, 461–465 (2006).
Xia, Y.F., Li, Y.D., Li, X. & Geng, J.G. Biochem. Biophys. Res. Commun. 296, 406–412 (2002).
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Hunter, C. Act1-ivating IL-17 inflammation. Nat Immunol 8, 232–234 (2007). https://doi.org/10.1038/ni0307-232
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DOI: https://doi.org/10.1038/ni0307-232
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