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Coincidence detection of antibodies and interferon for sensing microbial context

Nature Immunology volume 15, pages 316–317 (2014)Cite this article

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Functional coupling of receptors for immunoglobulin G (FcγRI) and interferon-γ (IFN-γR) generates a context-dependent signaling pathway in macrophages.

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Figure 1: IFN-γR and FcγRI form a functional complex that acts as a context detector in phagocytes.

Katie Vicari

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Authors and Affiliations

  1. Marc Daëron is with the Centre d'Immunologie de Marseille-Luminy, INSERM U1104, Marseille, France, CNRS UMR7280, Marseille, France, Aix Marseille Université UM2, Marseille, France, and Institut Pasteur, Paris, France.,

    Marc Daëron

  2. Eric Vivier is with the Centre d'Immunologie de Marseille-Luminy, INSERM U1104, Marseille, France, CNRS UMR7280, Marseille, France, Aix Marseille Université UM2, Marseille, France, and Service d'Immunologie, Assistance Publique–Hôpitaux de Marseille, Hôpital de la Conception, Marseille, France.,

    Eric Vivier

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  1. Marc Daëron
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  2. Eric Vivier
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Correspondence to Marc Daëron or Eric Vivier.

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Competing interests

E.V. is a cofounder and shareholder of Innate Pharma.

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Daëron, M., Vivier, E. Coincidence detection of antibodies and interferon for sensing microbial context. Nat Immunol 15, 316–317 (2014). https://doi.org/10.1038/ni.2851

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