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Lack of support for association between common variation in TNFSF4 and myocardial infarction in a German population

Nature Genetics volume 40, pages 1386–1387 (2008)Cite this article

A Correspondence to this article was published on 01 December 2008

To the Editor:

Evidence for a role of membrane glycoprotein TNFSF4, also known as OX40 ligand, in atherosclerosis has been obtained in studies with mice and humans1,2,3. The mouse homolog (Tnfsf4) of the human TNFSF4 gene underlies Ath1, a quantitative trait locus that renders C57BL/6 mice susceptible and C3H/He mice resistant to diet-induced atherosclerosis1,2. A SNP and SNP-based haplotypes of TNFSF4 have been associated with risk of myocardial infarction in two independent populations from Sweden1. However, these findings were limited by the inclusion of a small number of SNPs covering only a portion of the common variation near TNFSF4. To perform a comprehensive analysis of the association between TNFSF4 variation and myocardial infarction, we examined 14 different SNPs that together represented the great majority of variation within a 40-kb region encompassing TNFSF4 (Supplementary Fig. 1 online) in a case-control sample from Germany.

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Acknowledgements

The authors thank C. Ganser, W. Latz, M. Eichinger, U. Weiss and A. del Pozo Ben for technical assistance. This work was funded by a grant from Deutsches Herzzentrum München (KKF 1.4-05) to W.K.

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Author notes

  1. wkoch@dhm.mhn.de.

Authors and Affiliations

  1. Deutsches Herzzentrum München and 1. Medizinische Klinik, Klinikum rechts der Isar, Technische Universität München, Munich, 81675, Germany

    Werner Koch, Petra Hoppmann, Albert Schömig & Adnan Kastrati

  2. Department of Behavioural Ecology and Evolutionary Genetics, Max Planck Institute for Ornithology, Starnberg (Seewiesen), 82319, Germany

    Jakob C Mueller

Authors
  1. Werner Koch
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  2. Petra Hoppmann
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Supplementary information

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Supplementary Methods, Supplementary Tables 1–3 and Supplementary Figures 1 and 2 (PDF 125 kb)

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Koch, W., Hoppmann, P., Mueller, J. et al. Lack of support for association between common variation in TNFSF4 and myocardial infarction in a German population. Nat Genet 40, 1386–1387 (2008). https://doi.org/10.1038/ng1208-1386

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