Somatic loss-of-heterozygosity can result in the complete loss of function of tumor suppressor genes in human cancer. Mitotic recombination between homologous chromosomes can cause loss of heterozygosity, leading to tumorigenesis. However, the molecular mechanisms triggering and controlling mitotic recombination are largely unknown. A new study shows that genetic divergence between homologous chromosomes suppresses mitotic recombination to a varying degree in different tissues of the mouse.
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References
Biggins, S. & Murray A.W. Curr. Opin. Genet. Dev. 9, 230–236 (1999).
Johnson, R.D. & Jasin M. EMBO J. 19, 3398–3407 (2000).
Cavenee, W.K. et al. Nature 305, 779–784 (1983).
Morley, A.A. et al. Cancer Res. 50, 4584–4587 (1990).
Gupta, P.K. et al. Cancer Res. 57, 1188–1193 (1997).
de Nooij-Van Dalen, A.G. et al. Genes Chromosomes Cancer 30, 323–335 (2001).
Van Sloun, P.P. et al. Nucleic Acids Res. 26, 4888–4894 (1998).
Shao, C. et al. Proc. Natl. Acad. Sci. USA 96, 9230–9235 (1999).
Shao, C. et al. Nature. Genet. 28, 169–172 (2001)
van Heemst, D. & Heyting C. Chromosoma 109, 10–26 (2000).
Ellis, N.A. et al. Cell 83, 655–666 (1995).
Luo, G. et al. Nature. Genet. 26, 424–429 (2000).
Wu, L. & Hickson I.D. Science 292, 229–230 (2001).
de Wind, N. et al. Cell 82, 321–330 (1995).
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Vrieling, H. Mitotic maneuvers in the light. Nat Genet 28, 101–102 (2001). https://doi.org/10.1038/88794
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DOI: https://doi.org/10.1038/88794
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