A new study attempts to amplify and clone all the predicted protein-encoding open reading frames (ORFs) for Caenorhabditis elegans. This analysis confirms many of the predicted genes but suggests roughly 50% of them require correction. Recombining the ORFs into a number of different expression systems can generate functional proteomics kits for characterizing protein activity and interaction networks.
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Boone, C., Andrews, B. ORFeomics: correcting the wiggle in worm genes. Nat Genet 34, 8–9 (2003). https://doi.org/10.1038/ng0503-8
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DOI: https://doi.org/10.1038/ng0503-8
