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Reply to 'Assessing the validity of the association between the SUMO4 M55V variant and risk of type 1 diabetes'

Nature Genetics volume 37, pages 112–113 (2005)Cite this article

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We reported highly significant evidence for association between type 1 diabetes (T1D) and the gene SUMO4 (ref. 1). Two studies presented in this issue (Smyth et al. and Qu et al.) do not support our initial observation, but a third study in the Korean population provides confirmatory evidence (Park et al.). Such discrepant associations have been reported for many complex diseases, including T1D. The discrepancies may be caused by genotyping errors, random variation due to small sample size, spurious association, genetic heterogeneity or population differences in gene-gene and gene-environment interactions.

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  1. Center for Biotechnology and Genomic Medicine, Medical College of Georgia, 1120 15th Street, CA4124, Augusta, 30912, Georgia, USA

    Cong-Yi Wang, Ping Yang & Jin-Xiong She

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  1. Cong-Yi Wang
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  2. Ping Yang
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  3. Jin-Xiong She
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Correspondence to Jin-Xiong She.

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Wang, CY., Yang, P. & She, JX. Reply to 'Assessing the validity of the association between the SUMO4 M55V variant and risk of type 1 diabetes'. Nat Genet 37, 112–113 (2005). https://doi.org/10.1038/ng0205-112b

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