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Assessing the validity of the association between the SUMO4 M55V variant and risk of type 1 diabetes

Nature Genetics volume 37, pages 110–111 (2005)Cite this article

An Erratum to this article was published on 01 March 2005

To the editor:

Two groups recently reported evidence for association of a common nonsynonymous SNP (163A→G or rs237025, resulting in the amino acid substitution M55V) in the gene small ubiquitin-related modifier 4 (SUMO4) with type 1 diabetes (T1D)1,2,3. But an inconsistency is evident in a comparison of their results: Bohren et al.1 claimed that the 163A allele was positively associated with disease susceptibility, whereas Guo et al.2 reported that the nonconserved 163G allele was causal. We noted that in Guo et al.'s study of 944 families, the transmissions for these alleles in 92 UK multiplex families (from the Diabetes UK Warren repository) were in the opposite direction to the rest of their family results and case-control analyses, with the 163A allele transmitted at 56% (149 transmissions), whereas the 163G allele was transmitted at 58.6% in the rest of the families (922 transmissions). The inclusion of the 92 UK multiplex families had a large effect on the P value reported by Guo et al. (P = 1.9 × 10−7 to 2.9 × 10−5). Moreover, their results from these 92 UK families were consistent with the increased transmission of the 163G allele observed by Bohren et al., who analyzed 222 UK families from the Warren repository (which probably included the 92 families studied by Guo et al.) and 256 European American families (from the Human Biological Data Interchange collection)1,3.

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References

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Authors
  1. Deborah J Smyth
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  2. Joanna M M Howson
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  3. Christopher E Lowe
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  4. Neil M Walker
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  5. Alex C Lam
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  6. Sarah Nutland
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  10. Cristian Guja
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  11. Constantin Ionescu-Tîrgoviste
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  13. Kjersti S Rønningen
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  19. John A Todd
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Smyth, D., Howson, J., Lowe, C. et al. Assessing the validity of the association between the SUMO4 M55V variant and risk of type 1 diabetes. Nat Genet 37, 110–111 (2005). https://doi.org/10.1038/ng0205-110

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