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Induced mitotic recombination: a switch in time

It makes sense that our genome has evolved to have two copies of every gene—just in case something goes wrong, you still have a spare. But from the perspective of a geneticist, a diploid genome makes finding causative genes somewhat of a challenge, or at best, time consuming. One solution may be induced mitotic recombination.

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Figure 1

BOB CRIMI

Figure 2: Cre-ating a mosaic.

BOB CRIMI

References

  1. Liu, P., Jenkins, N.A. & Copeland, N.G. Nature Genet. 30, 66–72 (2002).

    Article  CAS  Google Scholar 

  2. Golic, K.G. Science 252, 958–961 (1991).

    Article  CAS  Google Scholar 

  3. Gu, H., Marth, J.D., Orban, P.C., Mossmann, H. & Rajewsky, K. Science 265, 103–106 (1994).

    Article  CAS  Google Scholar 

  4. Abuin, A. & Bradley, A. Mol. Cell. Biol. 16, 1851–1856 (1996).

    Article  CAS  Google Scholar 

  5. Mortensen, R.M., Conner, D.A., Chao, S., Geisterfer-Lowrance, A.A. & Seidman, J.G. Mol. Cell. Biol. 12, 2391–2395 (1992).

    Article  CAS  Google Scholar 

  6. Lefebvre, L., Dionne, N., Karaskova, J., Squire, J.A. & Nagy, A. Nature Genet. 27, 257–258 (2001).

    Article  CAS  Google Scholar 

  7. Luo, G. et al. Nature Genet. 26, 424–429 (2000).

    Article  CAS  Google Scholar 

Download references

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Adams, D., Bradley, A. Induced mitotic recombination: a switch in time. Nat Genet 30, 6–7 (2002). https://doi.org/10.1038/ng0102-6

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