Genomic aberrations affecting genes in B cell differentiation are hallmarks of B-precursor acute lymphoblastic leukemia (ALL). A new whole-genome sequencing study of ETV6-RUNX1–positive ALL has now identified RAG-mediated recombination, which specifically targets genes and regulatory elements active during B cell differentiation, as the underlying mechanism.
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Kuiper, R., Waanders, E. A RAG driver on the road to pediatric ALL. Nat Genet 46, 96–98 (2014). https://doi.org/10.1038/ng.2879
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DOI: https://doi.org/10.1038/ng.2879
