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Can preoperative PSA doubling time and PSA velocity predict outcomes following radical prostatectomy?

Nature Clinical Practice Urology volume 3, pages 306–307 (2006)Cite this article

boxed-textSengupta S et al. (2005) Preoperative prostate specific antigen doubling time and velocity are strong and independent predictors of outcomes following radical prostatectomy. J Urol 174: 2191–2196

Although definitive thresholds have not yet been established, studies indicate that men with a short PSA doubling time or rapid PSA velocity should be considered for more aggressive therapy

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Acknowledgements

The synopsis was written by Sandra Ford, Associate Editor, Nature Clinical Practice.

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Authors and Affiliations

  1. Division of Urologic Surgery,

    Robert L Grubb III & Gerald L Andriole

  2. Division of Urologic Surgery, at Washington University School of Medicine, St Louis, MO, USA

    Robert L Grubb III & Gerald L Andriole

Authors
  1. Robert L Grubb III
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  2. Gerald L Andriole
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Corresponding author

Correspondence to Gerald L Andriole.

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Competing interests

Dr Andriole is the Principal Investigator and Chairman of the Prostate Committee of PLCO, an NCI-sponsored long-term trial assessing the role of PSA testing in screening.

Dr Grubb is an Investigator for the Prostate Committee of the PLCO.

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Grubb, R., Andriole, G. Can preoperative PSA doubling time and PSA velocity predict outcomes following radical prostatectomy?. Nat Rev Urol 3, 306–307 (2006). https://doi.org/10.1038/ncpuro0476

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