Abstract
Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease, in which neuropsychiatric manifestations are a common cause of significant morbidity. The American College of Rheumatology has identified 19 distinct neuropsychiatric syndromes associated with SLE, although the 1982 American College of Rheumatology classification criteria for SLE recognize only two: seizures and psychosis. Neurocognitive impairment (NCI) is one of the most common and clinically challenging manifestations of SLE, but its pathophysiology remains poorly understood. This Review examines the epidemiology and pathophysiology of NCI in children and adolescents with SLE, as well as the diagnostic and therapeutic approaches that are available for these patients. As few published studies specifically address NCI in pediatric SLE, new directions for research are also discussed.
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Acknowledgements
This publication was made possible by Grant Number 5K23AR53202 from National Institutes of Arthritis and Musculoskeletal and Skin Diseases.
Désirée Lie, University of California, Irvine, CA, is the author of and is solely responsible for the content of the learning objectives, questions and answers of the Medscape-accredited continuing medical education activity associated with this article.
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Levy, D., Ardoin, S. & Schanberg, L. Neurocognitive impairment in children and adolescents with systemic lupus erythematosus. Nat Rev Rheumatol 5, 106–114 (2009). https://doi.org/10.1038/ncprheum0988
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DOI: https://doi.org/10.1038/ncprheum0988
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