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Can noninvasive imaging of biomarkers improve clinical grading of pediatric brain tumors?

Nature Clinical Practice Oncology volume 2, pages 336–337 (2005)Cite this article

boxed-textAstrakas LG et al. (2004) Noninvasive magnetic resonance spectroscopic imaging biomarkers to predict the clinical grade of pediatric brain tumors. Clin Cancer Res 10: 8220–8228

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References

  1. Pandya HG et al. (2005) The nonspecific nature of proton spectroscopy in brain masses in children: a series of demyelinating lesions. Neuroradiology [10.1007/s00234-003-0947-7]

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Acknowledgements

The synopsis was written by Emma Campbell, Associate Editor, Nature Clinical Practice.

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Authors and Affiliations

  1. the Chief of Pediatric Radiology at Massachusetts General Hospital in Boston, MA, USA

    P Ellen Grant

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  1. P Ellen Grant
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Correspondence to P Ellen Grant.

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The author declares no competing financial interests.

Glossary

WHO (2000) CLASSIFICATION

A World Health Organization classification system for brain tumors, taking into account their clinical course and histological characteristics, immunophenotypic features and molecular and cytogenetic profile

Z TEST

A statistical test that compares the difference in proportions between sets of data—or individual members within those sets of data—using normalized data, or z values

RECEIVER OPERATING CHARACTERISTIC CURVE

A statistical validation tool used to measure how well logistic regression models have predicted a particular binary outcome; the area under the curve equates to the probability of being able to discriminate between the two possible outcomes, with the ideal value being 1.0

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Grant, P. Can noninvasive imaging of biomarkers improve clinical grading of pediatric brain tumors?. Nat Rev Clin Oncol 2, 336–337 (2005). https://doi.org/10.1038/ncponc0203

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