Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Practice Point
  • Published:

Can pathological patterns be used to guide individualized multiple sclerosis therapy?

Nature Clinical Practice Neurology volume 2, pages 72–73 (2006)Cite this article

boxed-textKeegan et al. (2005) Relation between humoral pathological changes in multiple sclerosis and response to therapeutic plasma exchange. Lancet 366: 579–581

When unresponsive to high-dose glucocorticosteroid, severe MS relapses are probably caused by inflammatory demyelination driven by autoantibodies or complement; in these cases therapeutic plasma exchange should be considered

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

  1. Lassmann H et al. (2001) Heterogeneity of multiple sclerosis pathogenesis: implications for diagnosis and therapy. Trends Mol Med 7: 115–121

    Article  CAS  Google Scholar 

  2. Weinshenker BG et al. (1999) A randomized trial of plasma exchange in acute central nervous system inflammatory demyelinating disease. Ann Neurol 46: 878–886

    Article  CAS  Google Scholar 

  3. Ruprecht K et al. (2004) Plasma exchange for severe optic neuritis—treatment of 10 patients. Neurology 63: 1081–1083

    Article  CAS  Google Scholar 

  4. Gold R et al. (1997) T-cell apoptosis in autoimmune diseases: termination of inflammation in the nervous system and other sites with specialized immune-defense mechanisms. Trends Neurosci 20: 399–404

    Article  CAS  Google Scholar 

  5. Chan A et al. (2005) Mitoxantrone induces cell death in peripheral blood leucocytes of multiple sclerosis patients. Clin Exp Immunol 139: 152–158

    Article  CAS  Google Scholar 

Download references

Acknowledgements

The synopsis was written by Andrew Chan and Ralf Gold.

Author information

Authors and Affiliations

  1. Neurology, affiliated as a clinical neuroimmunologist to the Institute of MS-research, University of Goettingen,

    Andrew Chan & Ralf Gold

  2. Institute for Multiple Sclerosis Research, University of Goettingen and Gemeinnützige, Hertie-Stiftung, Goettingen, Germany

    Andrew Chan & Ralf Gold

Authors
  1. Andrew Chan
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Ralf Gold
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Ralf Gold.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Supplementary information

Supplementary Figure 1

Immunopathological patterns I-IV in active multiple sclerosis lesions.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Chan, A., Gold, R. Can pathological patterns be used to guide individualized multiple sclerosis therapy?. Nat Rev Neurol 2, 72–73 (2006). https://doi.org/10.1038/ncpneuro0120

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1038/ncpneuro0120

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing