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What is the optimal anti-inflammatory therapy for patients with osteoarthritis and increased cardiovascular risk?

Nature Clinical Practice Gastroenterology & Hepatology volume 5, pages 240–241 (2008)Cite this article

boxed-textGoldstein JL et al. (2007) Celecoxib plus aspirin versus naproxen and lansoprazole plus aspirin: a randomized, double-blind, endoscopic trial. Clin Gastroenterol Hepatol 5: 1167–1174

Patients with osteoarthritis, a high gastrointestinal risk and a low cardiovascular risk should receive a PPI plus a low-dose COX-2 selective NSAID; patients in whom cardiovascular risk parallels or exceeds gastrointestinal risk should receive aspirin, naproxen plus a PPI

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References

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Acknowledgements

The synopsis was written by Rachel Jones, Associate Editor, Nature Clinical Practice.

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Authors and Affiliations

  1. LH Lai is a Fellow and FLK Chan is Professor of Medicine and Chief of Gastroenterology and Hepatology at the Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong, China.,

    Larry H Lai & Francis LK Chan

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  1. Larry H Lai
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  2. Francis LK Chan
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Correspondence to Francis LK Chan.

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Lai, L., Chan, F. What is the optimal anti-inflammatory therapy for patients with osteoarthritis and increased cardiovascular risk?. Nat Rev Gastroenterol Hepatol 5, 240–241 (2008). https://doi.org/10.1038/ncpgasthep1120

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