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How useful is thiopurine metabolite monitoring in pediatric inflammatory bowel disease?

Nature Clinical Practice Gastroenterology & Hepatology volume 5, pages 12–13 (2008)Cite this article

boxed-textOoi CY et al. (2007) Thiopurine metabolite monitoring in paediatric inflammatory bowel disease. Aliment Pharmacol Ther 25: 941–947

Thiopurine metabolite monitoring should be used to guide treatment, or, at the very least, provide an effective means of monitoring adherence to therapy in patients with IBD

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References

  1. Cuffari C et al. (2001) Utilization of erythrocyte 6-thioguanine metabolite levels to optimize therapy in IBD. Gut 48: 642–646

    Article  CAS  Google Scholar 

  2. Reinshagen M et al. (2007) 6-thioguanine nucleotide-adapted azathioprine therapy does not lead to higher remission rates than standard therapy in chronic active Crohn disease: results from a randomized controlled, open trial. Clin Chem 53: 1306–1314.

    Article  CAS  Google Scholar 

  3. Dubinsky MC et al. (2002) 6-MP metabolite profiles provide a biochemical explanation for 6-MP resistance in patients with inflammatory bowel disease. Gastroenterology 122: 904–915

    Article  CAS  Google Scholar 

  4. Cuffari C et al. (2004) Thiopurine methyl-transferase activity influences clinical response to azathioprine therapy in patients with IBD. Clin Gastroenterol Hepatol 2: 410–417

    Article  CAS  Google Scholar 

  5. Sparrow MP et al. (2007) Effect of allopurinol on clinical outcomes in inflammatory bowel disease non-responders to azathioprine or 6-mercaptopurine. Clin Gastroenterol Hepatol 5: 209–214

    Article  CAS  Google Scholar 

  6. Osterman MT et al. (2006) Association of 6-thioguanine nucleotide levels and inflammatory bowel disease activity: a meta-analysis. Gastroenterology 130: 1047–1053

    Article  CAS  Google Scholar 

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Acknowledgements

The synopsis was written by Rachel Jones, Associate Editor, Nature Clinical Practice.

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  1. The Johns Hopkins Hospital, 600 North Wolfe Street, Brady 320, Baltimore, MD 21287, USA ccuffari@jhmi.com

Authors and Affiliations

  1. C Cuffari is Associate Professor of Pediatrics at The Johns Hopkins University, Baltimore, MD, USA.,

    Carmen Cuffari

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  1. Carmen Cuffari
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Competing interests

C Cuffari is a Consultant and Speaker for, and has received research support from, Prometheus.

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Cuffari, C. How useful is thiopurine metabolite monitoring in pediatric inflammatory bowel disease?. Nat Rev Gastroenterol Hepatol 5, 12–13 (2008). https://doi.org/10.1038/ncpgasthep0995

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