Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Practice Point
  • Published:

Is an antibiotic plus an antimotility agent superior to either agent alone for the treatment of travelers' diarrhea?

Nature Clinical Practice Gastroenterology & Hepatology volume 4, pages 652–653 (2007)Cite this article

boxed-textDupont HL et al. (2007) Treatment of travelers' diarrhea: randomized trial comparing rifaximin, rifaximin plus loperamide, and loperamide alone. Clin Gastroenterol Hepatol 5: 451–456

Rifaximin plus loperamide is marginally superior to rifaximin alone for travelers' diarrhea; however, rifaximin alone might be a better treatment choice because of the unknown effects of rifaximin plus loperamide in patients infected with invasive enteropathogens

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

  1. [No authors listed] (2004) Rifaximin (Xifaxan) for travelers' diarrhea. Med Lett Drugs Ther 46: 74–75

  2. Ericcson CD et al. (1990) Treatment of traveler's diarrhea with sulfamethoxazole and trimethoprim and operamide. JAMA 263: 257–261

    Article  Google Scholar 

  3. Taylor DN et al. (1991) Treatment of travelers' diarrhea: ciprofloxacin plus loperamide compared with ciprofloxacin alone: a placebo-controlled, randomized trial. Ann Intern Med. 114: 731–734

    Article  CAS  Google Scholar 

  4. Sanders JW et al. (2007) Azithromycin and loperamide are comparable to levofloxacin and loperamide for the treatment of traveler's diarrhea in United States military personnel in Turkey. Clin Infect Dis 45: 294–301

    Article  CAS  Google Scholar 

  5. Murphy GS et al. (1993) Ciprofloxacin and loperamide in the treatment of bacillary dysentery. Ann Intern Med 118: 582–586

    Article  CAS  Google Scholar 

  6. Petruccelli BP et al. (1992) Treatment of traveler's diarrhea with ciprofloxacin and loperamide. J Infect Dis 165: 557–560

    Article  CAS  Google Scholar 

Download references

Acknowledgements

The synopsis was written by Rachel Jones, Associate Editor, Nature Clinical Practice.

Author information

Authors and Affiliations

  1. AL Baroco is a Fellow and EC Oldfield is Director of the Division of Infectious Diseases, Department of Medicine, at Eastern Virginia Medical School, Norfolk, VA, USA.,

    Allison L Baroco & Edward C Oldfield

Authors
  1. Allison L Baroco
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Edward C Oldfield
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Allison L Baroco.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Baroco, A., Oldfield, E. Is an antibiotic plus an antimotility agent superior to either agent alone for the treatment of travelers' diarrhea?. Nat Rev Gastroenterol Hepatol 4, 652–653 (2007). https://doi.org/10.1038/ncpgasthep0981

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/ncpgasthep0981

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing