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Should PPIs be given to patients on antiplatelet drugs?

Nature Clinical Practice Gastroenterology & Hepatology volume 3, pages 428–429 (2006)Cite this article

boxed-textIbáñez L et al. (2006) Upper gastrointestinal bleeding associated with antiplatelet drugs. Aliment Pharmacol Ther 23: 235–242

PPIs should be used in all patients on antiplatelet therapy who have additional risks for upper gastrointestinal bleeding (e.g. a history of peptic ulcer or upper gastrointestinal bleeding, or antecedents of dyspepsia)

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References

  1. Patrono C et al. (2004) Expert consensus document on the use of antiplatelet agents. Eur Heart J 25: 166–181

    Article  Google Scholar 

  2. Chan FK et al. (2001) Preventing recurrent upper gastrointestinal bleeding in patients with Helicobacter pylori infection who are taking low-dose aspirin or naproxen. N Engl J Med 344: 967–973

    Article  CAS  Google Scholar 

  3. Lai KC et al. (2002) Lansoprazole for the prevention of recurrences of ulcer complications from long-term low-dose aspirin use. N Engl J Med 346: 2033–2038

    Article  CAS  Google Scholar 

  4. Chan FK et al. (2005) Clopidogrel versus aspirin and esomeprazole to prevent recurrent ulcer bleeding. N Engl J Med 352: 238–244

    Article  CAS  Google Scholar 

  5. Lanas A et al. (2000) Nitrovasodilators, low-dose aspirin, other nonsteroidal antiinflammatory drugs, and the risk of upper gastrointestinal bleeding. N Engl J Med 343: 834–849

    Article  CAS  Google Scholar 

  6. Ng FH et al. (2004) Clopidogrel plus omeprazol compared with aspirin plus omeprazole for aspirin-induced symptomatic peptic ulcers/erosions with low to moderate bleeding/re-bleeding risk—a single-blind randomized controlled study. Aliment Pharmacol Ther 19: 359–365

    Article  CAS  Google Scholar 

Download references

Acknowledgements

The synopsis was written by Rachel Jones, Associate Editor, Nature Clinical Practice.

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Authors and Affiliations

  1. Fellow, Division of Gastroenterology and Hepatology at the University Hospital of Zurich, Zurich, Switzerland

    Stephan R Vavricka

  2. Staff Physician, Division of Gastroenterology and Hepatology at the University Hospital of Zurich, Zurich, Switzerland

    Stephan M Wildi

  3. Director of the Division of Gastroenterology and Hepatology at the University Hospital of Zurich, Zurich, Switzerland

    Michael Fried

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  1. Stephan R Vavricka
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  2. Stephan M Wildi
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  3. Michael Fried
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Correspondence to Stephan R Vavricka.

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Vavricka, S., Wildi, S. & Fried, M. Should PPIs be given to patients on antiplatelet drugs?. Nat Rev Gastroenterol Hepatol 3, 428–429 (2006). https://doi.org/10.1038/ncpgasthep0559

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