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Is ursodeoxycholic acid effective for the prevention of colorectal adenoma recurrence?

Nature Clinical Practice Gastroenterology & Hepatology volume 2, pages 512–513 (2005)Cite this article

boxed-textAlberts DS et al. (2005) Phase III trial of urosedoxycholic acid to prevent colorectal adenoma recurrence. J Natl Cancer Inst 97: 846–853

Ursodeoxycholic acid failed to reduce sporadic adenoma recurrence rates significantly and, therefore, cannot be recommended for colorectal cancer chemoprevention

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References

  1. Earnest DL et al. (1994) Chemoprevention of azoxymethane-induced colonic carcinogenesis by supplemental dietary ursodeoxycholic acid. Cancer Res 54: 5071–5074

    CAS  PubMed  Google Scholar 

  2. Khare S et al. (2003) Ursodeoxycholic acid inhibits Ras mutations, wild-type Ras activation, and cyclooxygenase-2 expression in colon cancer. Cancer Res 63: 3517–3523

    CAS  PubMed  Google Scholar 

  3. Pardi DS et al. (2003) Ursodeoxycholic acid as a chemopreventive agent in patients with ulcerative colitis and primary sclerosing cholangitis. Gastroenterology 124: 889–893

    Article  CAS  Google Scholar 

  4. Sandler RS et al. (2003) A randomized trial of aspirin to prevent colorectal adenomas in patients with previous colorectal cancer. N Engl J Med 348: 883–890

    Article  CAS  Google Scholar 

  5. Baron JA et al. (2003) A randomized trial of aspirin to prevent colorectal adenomas. N Engl J Med 348: 891–899

    Article  CAS  Google Scholar 

Download references

Acknowledgements

The synopsis was written by Rachel Jones, Associate Editor, Nature Clinical Practice.

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  1. Associate Professor of Medicine at the Mayo Clinic and Mayo College of Medicine, Rochester, MN, USA

    Frank Sinicrope

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  1. Frank Sinicrope
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Sinicrope, F. Is ursodeoxycholic acid effective for the prevention of colorectal adenoma recurrence?. Nat Rev Gastroenterol Hepatol 2, 512–513 (2005). https://doi.org/10.1038/ncpgasthep0322

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