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Does nadolol improve the efficacy of endoscopic variceal ligation in the treatment of variceal bleeding?

Nature Clinical Practice Gastroenterology & Hepatology volume 2, pages 254–255 (2005)Cite this article

boxed-textde la Peña J et al. (2005) Variceal ligation plus nadolol compared with ligation for prophylaxis of variceal rebleeding: a multicenter trial. Hepatology 41: 572–578

A combined therapy of EVL and a nonselective β-blocker is an effective approach for the secondary prophylaxis of patients with variceal hemorrhages

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References

  1. Villanueva C et al. (2001) Endoscopic ligation compared with combined treatment with nadolol and isosorbide mononitrate to prevent recurrent variceal bleeding. N Engl J Med 345: 647–655

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Acknowledgements

The synopsis was written by Rachel Jones, Associate Editor, Nature Clinical Practice.

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Authors and Affiliations

  1. Professor Mayo Clinic College of Medicine, Rochester, MN, USA

    Patrick S Kamath

  2. Associate Professor at Mayo Clinic College of Medicine, Rochester, MN, USA

    Vijay Shah

Authors
  1. Patrick S Kamath
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  2. Vijay Shah
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Correspondence to Patrick S Kamath.

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The authors declare no competing financial interests.

Glossary

ESOPHAGOGASTRIC TYPE GASTROESOPHAGEAL VARICES 1

Varices (2–5 cm in length) that extend across the gastroesophageal junction along the lesser curve

HEPATIC VENOUS PRESSURE GRADIENT MONITORING

Indirect assessment of portal pressure obtained by wedging a balloon catheter into the hepatic vein under radiographic guidance

CHILD–TURCOTTE–PUGH CLASS

A scoring system used to evaluate prognosis of cirrhosis. Depending upon the serum levels of bilirubin and albumin, prothrombin time, ascites, and encephalopathy, patients are divided into classes A (score 5–6), B (7–9) and C (10–15)

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Kamath, P., Shah, V. Does nadolol improve the efficacy of endoscopic variceal ligation in the treatment of variceal bleeding?. Nat Rev Gastroenterol Hepatol 2, 254–255 (2005). https://doi.org/10.1038/ncpgasthep0189

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