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What is the long-term effect of high-dose versus standard-dose omeprazole in patients with dyspepsia?

Nature Clinical Practice Gastroenterology & Hepatology volume 1, pages 12–13 (2004)Cite this article

boxed-textMeineche-Schmidt V (2004) Empiric treatment with high and standard dose of omeprazole in general practice: two-week randomized placebo-controlled trial and 12-month follow-up of health-care consumption. Am J Gastroenterol 99: 1059–1062

Treatment of dyspepsia should start with standard-dose PPI therapy because high-dose therapy seems to offer no additional benefits

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References

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Acknowledgements

The synopsis was written by Waheed Bhatti, Assistant Editor, Nature Clinical Practice.

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Authors and Affiliations

  1. Chief of the Division of Gastroenterology at the Dallas Veterans Affairs Medical Center and Professor of Medicine at University of Texas Southwestern Medical Center, Dallas, Texas, USA

    Stuart J Spechler

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  1. Stuart J Spechler
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Correspondence to Stuart J Spechler.

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Competing interests

Dr Spechler receives grant support from AstraZeneca and Novartis. He is also on the speaker's bureau for AstraZeneca, TAP and Janssen.

Glossary

ALARM SYMPTOMS

Signs of serious disease, such as bleeding, weight loss, vomiting or jaundice

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Spechler, S. What is the long-term effect of high-dose versus standard-dose omeprazole in patients with dyspepsia?. Nat Rev Gastroenterol Hepatol 1, 12–13 (2004). https://doi.org/10.1038/ncpgasthep0006

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