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Ovarian hyperstimulation syndrome caused by an FSH-secreting pituitary adenoma

Nature Clinical Practice Endocrinology & Metabolism volume 4, pages 234–238 (2008)Cite this article

Abstract

Background A 40-year-old woman presented with galactorrhea and oligomenorrhea. She had a history of multiple ovarian cysts and pelvic pain.

Investigations Laboratory evaluation included measurements of the levels of estradiol, follicle-stimulating hormone, luteinizing hormone, prolactin, thyroid-stimulating hormone, free endogenous T4, the glycoprotein hormone α subunit, cortisol, adrenocorticotropic hormone, and insulin-like growth factor I. Radiological studies included MRI of the pituitary.

Diagnosis Ovarian hyperstimulation syndrome caused by a pituitary adenoma, secreting follicle-stimulating hormone.

Management The patient underwent trans-sphenoidal resection of the adenoma, with subsequent normalization of hormonal values and symptoms.

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Figure 1: The patient's pre-operative MRI depicting the pituitary mass.

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Acknowledgements

This work was supported by NIH grants T32 DK007770-06A2 and CA75979. Consent for the publication of Figure 1 was obtained from the patient.

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Authors and Affiliations

  1. O Cooper is a Research Fellow in Endocrinology, JL Geller is a Clinical Endocrinologist and S Melmed is the Director of the Burns and Allen Research Institute and Senior Vice President of Academic Affairs, all at the Cedars-Sinai Medical Center, Los Angeles, CA, USA.,

    Odelia Cooper, Jordan L Geller & Shlomo Melmed

Authors
  1. Odelia Cooper
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  2. Jordan L Geller
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  3. Shlomo Melmed
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Corresponding author

Correspondence to Shlomo Melmed.

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The authors declare no competing financial interests.

Supplementary information

Supplementary Table 1

Similar cases described in the literature. Clinical presentation. (DOC 125 kb)

Supplementary Table 2

Similar cases described in the literature. Biochemical profiles. (DOC 125 kb)

Supplementary Table 3

Similar cases described in the literature. Treatment and postoperative course. (DOC 125 kb)

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Cooper, O., Geller, J. & Melmed, S. Ovarian hyperstimulation syndrome caused by an FSH-secreting pituitary adenoma. Nat Rev Endocrinol 4, 234–238 (2008). https://doi.org/10.1038/ncpendmet0758

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