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The metabolic syndrome as a risk factor in simultaneous kidney–pancreas transplantation

Nature Clinical Practice Endocrinology & Metabolism volume 3, pages 498–499 (2007)Cite this article

Advances in immunosuppressive drug therapy in kidney transplantation have considerably reduced the risk of acute rejection, and resulted in a marked improvement in short-term renal allograft survival. Unfortunately, however, long-term renal allograft survival continues to be problematic, and almost half of all grafts fail within the first 12 years after transplantation.1

The primary etiology of late renal allograft failure is chronic renal transplant dysfunction (CRTD), which is characterized by a gradual decline in renal function over time that progresses at a variable rate among affected individuals.2 CRTD is believed to be the end result of a combination of multiple immunologic and nonimmunologic factors.3,4 CRTD during the first year after transplant tends to be associated with immunologic and ischemic processes, whereas CRTD beyond the first year seems to correlate with a variety of nonimmunologic factors, such as obesity, diabetes, hypertension, and dyslipidemia.5 In aggregate, these nonimmunologic risk factors constitute the metabolic syndrome.

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Authors and Affiliations

  1. J Rogers is an Associate Professor of Surgery and RJ Stratta is a Professor of Surgery and Director of Transplantation at Wake Forest University Baptist Medical Center, Winston-Salem, NC, USA.,

    Jeffrey Rogers & Robert J Stratta

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  1. Jeffrey Rogers
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  2. Robert J Stratta
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Correspondence to Jeffrey Rogers.

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The authors declare no competing financial interests.

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Rogers, J., Stratta, R. The metabolic syndrome as a risk factor in simultaneous kidney–pancreas transplantation. Nat Rev Endocrinol 3, 498–499 (2007). https://doi.org/10.1038/ncpendmet0534

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