Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Practice Point
  • Published:

Is long-term glucocorticoid therapy associated with a high prevalence of asymptomatic vertebral fractures?

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

References

  1. LoCascio V et al. (1990) Bone loss in response to long-term glucocorticoid therapy. Bone Miner 8: 39–51

    Article  CAS  Google Scholar 

  2. Van Staa TP et al. (2003) Bone density threshold and other predictors of vertebral fracture in patients receiving oral glucocorticoid therapy. Arthritis Rheum 48: 3224–3229

    Article  CAS  Google Scholar 

  3. Weinstein RS et al. (1998) Inhibition of osteoblastogenesis and promotion of apoptosis of osteoblasts and osteocytes by glucocorticoids: potential mechanisms of their deleterious effects on bone. J Clin Invest 102: 274–282

    Article  CAS  Google Scholar 

  4. O'Brien CA et al. (2004) Glucocorticoids act directly on osteoblasts and osteocytes to induce their apoptosis and reduce bone formation and strength. Endocrinology 145: 1835–1841

    Article  CAS  Google Scholar 

  5. Weinstein RS (2001) Glucocorticoid-induced osteoporosis. Rev Endocr Metab Disord 2: 65–73

    Article  CAS  Google Scholar 

Download references

Acknowledgements

The synopsis was written by Vicky Heath, Associate Editor, Nature Clinical Practice.

Author information

Authors and Affiliations

Authors

Ethics declarations

Competing interests

The author declares no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Weinstein, R. Is long-term glucocorticoid therapy associated with a high prevalence of asymptomatic vertebral fractures?. Nat Rev Endocrinol 3, 86–87 (2007). https://doi.org/10.1038/ncpendmet0372

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1038/ncpendmet0372

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing