Abstract
Background A 35-year-old man with primary antiphospholipid syndrome and no risk factors for atherosclerosis presented with postinfarction angina.
Investigations Coronary angiography, intravascular ultrasonography, injection of apolipoprotein–E-knockout mice with patient's IgG.
Diagnosis Myocardial infarction caused by a newly occluded proximal left circumflex artery. The left anterior descending artery exhibited a recanalized thrombus throughout the vessel.
Management The patient was managed by intensive angicoagulation including aspirin, clopidogrel, and enoxaparin for 2 months. After follow-up coronary angiography, he was switched to warfarin with a target International Normalized Ratio of 3.5–4.0.
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Adler, A., Afek, A., Levy, Y. et al. Antiphospholipid antibodies from a patient with primary antiphospholipid syndrome enhance experimental atherosclerosis. Nat Rev Cardiol 6, 215–218 (2009). https://doi.org/10.1038/ncpcardio1436
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DOI: https://doi.org/10.1038/ncpcardio1436