Abstract
McDermott et al. have demonstrated, for the first time, that a poor 6 min walk performance and slow walking speed in patients with peripheral arterial disease (PAD) are predictors of increased all-cause and cardiovascular mortality. The association was not affected by confounders, such as ankle brachial index and comorbidities. Simple measures of lower extremity functional performance could and should be incorporated into future research studies in patients with PAD. Reducing cardiovascular risk with statins, lowering blood pressure, and administering antiplatelet agents are not enough; measures to improve functional performance should be incorporated into overall cardiovascular risk reduction programs in patients with PAD.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Criqui MH et al. (1992) Mortality over a period of 10 years in patients with peripheral arterial disease. N Engl J Med 326: 381–386
Resnick HE et al. (2004) Relationship of high and low ankle brachial index to all-cause and cardiovascular disease mortality: the Strong Heart Study. Circulation 109: 733–739
Sikkink CJ et al. (1997) Decreased ankle/brachial indices in relation to morbidity and mortality in patients with peripheral arterial disease. Vasc Med 2: 169–173
Heald CL et al. for the Ankle Brachial Index Collaboration (2006) Risk of mortality and cardiovascular disease associated with the ankle-brachial index: systematic review. Atherosclerosis 189: 61–69
McDermott MM et al. (2008) Asymptomatic peripheral arterial disease is associated with more adverse lower extremity characteristics than intermittent claudication. Circulation 117: 2484–2491
McDermott MM et al. (2008) Prognostic value of functional performance for mortality in patients with peripheral artery disease. J Am Coll Cardiol 51: 1482–1489
McDermott MM et al. (2002) The ankle brachial index is associated with leg function and physical activity: the Walking and Leg Circulation Study. Ann Intern Med 136: 873–883
McDermott MM et al. (2001) Leg symptoms in peripheral arterial disease: associated clinical characteristics and functional impairment. JAMA 286: 1599–1606
Garg PK et al. (2006) Physical activity during daily life and mortality in patients with peripheral arterial disease. Circulation 114: 242–248
Gardner AW et al. (2001) Exercise rehabilitation improves functional outcomes and peripheral circulation in patients with intermittent claudication: a randomized controlled trial. J Am Geriatr Soc 49: 755–762
Author information
Authors and Affiliations
Ethics declarations
Competing interests
The author declares no competing financial interests.
Rights and permissions
About this article
Cite this article
Olin, J. Can functional performance be used as a simple prognostic indicator in peripheral arterial disease?. Nat Rev Cardiol 5, 686–687 (2008). https://doi.org/10.1038/ncpcardio1341
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/ncpcardio1341