Abstract
Stem cell therapy after acute myocardial infarction is a promising therapeutic strategy. Intermediate-sized clinical trials to answer many unanswered questions must be carefully designed and surrogate end points carefully chosen. Moreover, imaging techniques accurate enough to measure surrogate parameters and to make it possible to reduce sample size are needed. The imaging technique of choice in this setting should be capable of tracking the destiny of the stem cells once injected in the heart and of quantifying left ventricular remodelling parameters. This information will be crucial in the design of multicenter, large, randomized trials to assess survival, which can definitively establish the usefulness of this therapeutic strategy.
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References
Strauer BE et al. (2002) Repair of infarcted myocardium by autologous intracoronary mononuclear bone marrow cell transplantation in humans. Circulation 106: 1913–1918
Assmus B et al. (2002) Transplantation of progenitor cells and regeneration enhancement in acute myocardial infarction (TOPCARE-AMI). Circulation 106: 3009–3017
Fernández-Avilés F et al. (2004) Experimental and clinical regenerative capability of human bone marrow cells after myocardial infarction. Circ Res 95: 742–748
Wollert KC and Drexler H (2005) Clinical applications of stem cells for the heart. Circ Res 96: 151–163
Mathur A and Martin JF (2004) Stem cells and repair of the heart. Lancet 364: 183–192
Fleming TR and DeMets DL (1996) Surrogate end points in clinical trials: are we being misled? Ann Intern Med 125: 605–613
Bottini PB et al. (1995) Magnetic resonance imaging compared to echocardiography to assess left ventricular mass in the hypertensive patient. Am J Hypertens 8: 221–228
Murray JA et al. (1972) Echocardiographic determination of left ventricular dimensions, volumes and performance. Am J Cardiol 30: 252–257
Woythaler JN et al. (1983) Accuracy of echocardiography versus electrocardiography in detecting left ventricular hypertrophy: comparison with postmortem mass measurements. J Am Coll Cardiol 2: 305–311
Hoffman R et al. (2005) Assessment of systolic left ventricular function: a multi-centre comparison of cineventriculography, cardiac magnetic resonance imaging, unenhanced and contrast-enhanced echocardiography. Eur Heart J 26: 607–616
Bellenger NG et al. (2000) Reduction in sample size for studies of remodelling in heart failure by the use of cardiovascular magnetic resonance. J Cardiovasc Magn Res 2: 271–278
Gibbons RJ et al. (2004) The quantification of infarct size. J Am Coll Cardiol 44: 1533–1542
Wagner A et al. (2003) Contrast-enhanced MRI and routine single photon emission computed tomography (SPECT) perfusion imaging for detection of subendocardial myocardial infarcts: an imaging study. Lancet 361: 374–379
Mahrholdt H et al. (2002) Reproducibility of chronic infarct size measurement by contrast-enhanced magnetic resonance imaging. Circulation 106: 2322–2327
Frangioni JV and Hajjar RJ (2004) In vivo tracking of stem cells for clinical trials in cardiovascular disease. Circulation 110: 3378–3384
Massoud TF and Gambhir SS (2003) Molecular imaging in living subjects: seeing fundamental biological processes in a new light. Genes Dev 17: 545–580
Barbash IM et al. (2003) Systemic delivery of bone marrow-derived mesenchymal stem cells to the infarcted myocardium. Feasibility, cell migration, and body distribution. Circulation 108: 863–868
Wu JC et al. (2003) Molecular imaging of cardiac cell transplantation in living animals using optical bioluminescence and positron emission tomography. Circulation 1302–1305
Hinds KA et al. (2003) Highly efficient endosomal labelling of progenitor and stem cells with large magnetic particles allows magnetic resonance imaging of single cells. Blood 102: 867–872
Hill JM et al. (2003) Serial magnetic resonance imaging of injected mesenchymal stem cells. Circulation 108: 1009–1014
Garot J et al. (2003) Magnetic resonance imaging of targeted catheter-based implantation of myogenic precursor cells into infarcted left ventricular myocardium. J Am Coll Cardiol 41: 1841–1846
Kraitchman DL et al. (2003) In vivo magnetic resonance imaging of mesenchymal stem cells in myocardial infarction. Circulation 107: 2290–2293
Aicher A et al. (2003) Assessment of the tissue distribution of transplanted human endothelial progenitor cells by radioactive labelling. Circulation 107: 2134–2139
Hofmann M et al. (2005) Monitoring of bone marrow cell homing into the infarcted human myocardium. Circulation 111: 2198–2202
Corti R et al. (2005) Real time magnetic resonance guided endomyocardial local delivery. Heart 91: 348–353
Acknowledgements
The present work was partially financed by the Red de Centros Cardiovasculares (RECAVA) which is supported by the Instituto de Salud Carlos III, Spain.
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San Román, J., Fernández-Avilés, F. The role of noninvasive imaging techniques in the assessment of stem cell therapy after acute myocardial infarction. Nat Rev Cardiol 3 (Suppl 1), S38–S41 (2006). https://doi.org/10.1038/ncpcardio0448
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DOI: https://doi.org/10.1038/ncpcardio0448
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