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Mesenchymal lineage precursor cells induce vascular network formation in ischemic myocardium

Nature Clinical Practice Cardiovascular Medicine volume 3, pages S18–S22 (2006)Cite this article

Abstract

Mesenchymal lineage precursors can be reproducibly isolated from adult mammalian bone marrow and grown in culture. Immunoselection with monoclonal antibodies against STRO-1 and vascular-cell-adhesion molecule 1 (VCAM1/CD106) prior to expansion results in a 1,000-fold enrichment of mesenchymal precursors compared to standard isolation techniques. Intramyocardial injection of human STRO-1-selected precursors in an athymic rat model of acute myocardial infarction results in induction of vascular network formation and arteriogenesis coupled with global functional cardiac recovery.

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Figure 1: Induction of tumor neovascularization (angiogenesis and arteriogenesis) by human STRO-1bright cells
Figure 2: Dose-dependent effect of STRO-1bright cells on myocardial neovascularization
Figure 3: STRO-1bright-dependent myocardial neovascularization results in global improvement of parameters of myocardial function

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Authors and Affiliations

  1. Chief Research Fellow,

    Timothy P Martens, Fiona See, Michael D Schuster, Hugo P Sondermeijer, Marco M Hefti, Tetsunori Seki & Silviu Itescu

  2. Postdoctoral Research Fellows,

    Timothy P Martens, Fiona See, Michael D Schuster, Hugo P Sondermeijer, Marco M Hefti, Tetsunori Seki & Silviu Itescu

  3. Medical Student in the Division of Cardiothoracic Surgery,

    Timothy P Martens, Fiona See, Michael D Schuster, Hugo P Sondermeijer, Marco M Hefti, Tetsunori Seki & Silviu Itescu

  4. Associate Research Scientist,

    Timothy P Martens, Fiona See, Michael D Schuster, Hugo P Sondermeijer, Marco M Hefti, Tetsunori Seki & Silviu Itescu

  5. Assistant Professor and Director of Transplant Immunology in the Department of Surgery at Columbia University, New York, NY, USA

    Timothy P Martens, Fiona See, Michael D Schuster, Hugo P Sondermeijer, Marco M Hefti, Tetsunori Seki & Silviu Itescu

  6. Division of Haematology, Myeloma and Mesenchymal Research Laboratory, Hanson Institute, Adelaide, SA, Australia

    Andrew Zannettino & Stan Gronthos

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  1. Timothy P Martens
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Correspondence to Timothy P Martens.

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Martens, T., See, F., Schuster, M. et al. Mesenchymal lineage precursor cells induce vascular network formation in ischemic myocardium. Nat Rev Cardiol 3 (Suppl 1), S18–S22 (2006). https://doi.org/10.1038/ncpcardio0404

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  • DOI: https://doi.org/10.1038/ncpcardio0404

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