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Postinfarction heart failure: surgical and trans-coronary-venous transplantation of autologous myoblasts

Nature Clinical Practice Cardiovascular Medicine volume 3, pages S46–S51 (2006)Cite this article

Abstract

Increasing experimental evidence indicates that skeletal myoblasts can be considered as a possible source of cells for regeneration of contractile performance in chronic postinfarction myocardial injury. In experimental models, the observed functional benefit of transplanting skeletal myoblasts into an area of chronic fibrotic myocardial scar has led to the development of clinical trials to evaluate the potential use of autologous skeletal myoblasts for myocardial regeneration in patients with postinfarction heart failure. We conducted an independent, phase I clinical trial to evaluate myoblast transplantation during coronary artery bypass grafting. In addition, to test whether the effect of transplanted cells on myocardial contractility was independent of revascularization, we performed a clinical study of percutaneous transvenous myoblast transplantation—the POZNAN trial. These trials have shown the feasibility of myoblast transplantation during cardiac surgery and via a percutaneous route, as well as the safety of both procedures when performed with concurrent prophylactic administration of amiodarone. Here, we review the details of our observations from both of these phase I clinical trials in the context of the clinical work in cardiovascular cell transplantation performed by others.

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Figure 1: Myoblasts in culture for myocardial transplantation

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References

  1. Siminiak T and Kurpisz M (2003) Myocardial replacement therapy. Circulation 108: 1167–1171

    Article  Google Scholar 

  2. El Oakley RM et al. (2001) Myocyte transplantation for myocardial repair: a few good cells can mend a broken heart. Ann Thorac Surg 71: 1724–1733

    Article  CAS  Google Scholar 

  3. Taylor DA et al. (1998) Regenerating functional myocardium: improved performance after skeletal myoblast transplantation. Nat Med 4: 929–933

    Article  CAS  Google Scholar 

  4. Scorsin M et al. (2000) Comparison of the effects of fetal cardiomyocyte and skeletal myoblast transplantation on postinfarction left ventricular function. J Thorac Cardiovasc Surg 119: 1169–1175

    Article  CAS  Google Scholar 

  5. Siminiak T et al. (2002) Myoblast transplantation in the treatment of postinfarction myocardial contractility impairment. Kardiol Pol 56: 131–137

    Google Scholar 

  6. Siminiak T et al. (2004) Autologous skeletal myoblast transplantation for the treatment of postinfarction myocardial injury: phase I clinical study with 12 months of follow-up. Am Heart J 148: 531–537

    Article  Google Scholar 

  7. Siminiak T et al. (2003) Percutaneous autologous myoblast transplantation in the treatment of postinfarction myocardial contractility impairment – report on two cases. Kardiol Pol 59: 492–496

    PubMed  Google Scholar 

  8. Siminiak T et al. (2005) Percutaneous trans-coronary-venous transplantation of autologous skeletal myoblasts in the treatment of post-infarction myocardial contractility impairment. The POZNAN trial. Eur Heart J 26: 1188–1195

    Article  Google Scholar 

  9. Klug MG et al. (1996) Genetically selected cardiomyocytes from differentiating embryonic stem cells form stable intracardiac grafts. J Clin Invest 98: 216–224

    Article  CAS  Google Scholar 

  10. Tomita S et al. (1999) Autologous transplantation of bone marrow cells improves damaged heart function. Circulation 100 (Suppl 19): II-247–II-256

    CAS  Google Scholar 

  11. Li RK et al. (1996) In vivo survival and function of transplanted rat cardiomyocytes. Circ Res 78: 283–288

    Article  CAS  Google Scholar 

  12. Menasché P et al. (2001) Myoblast transplantation for heart failure. Lancet 357: 279–280

    Article  Google Scholar 

  13. American Society of Echocardiography Committee on Standards, Subcommittee on Quantitation of Two-Dimensional Echocardiograms (1989) Recommendations for quantitation of the left ventricle by two-dimensional echocardiography. Am Soc Echocardiogr 2: 358–367

  14. Rozwadowska N et al. (2002) Evaluation of in vitro culture of human myoblasts for tissue autotransplants to the post-infarction heart. Kardiol Pol 57: 233–241

    Google Scholar 

  15. Criteria Committee of the New York Heart Association (1994) Nomenclature and Criteria for Diagnosis of Diseases of the Heart and Great Vessels, 9th Edn, 253–256. Boston: Little, Brown

  16. Smits PC et al. (2003) Catheter-based intramyocardial injection of autologous skeletal myoblasts as a primary treatment of ischemic heart failure. Clinical experience with six-month follow-up. J Am Coll Cardiol 42: 2063–2069

    Article  Google Scholar 

  17. Reinecke H et al. (2000) Electromechanical coupling between skeletal and cardiac muscle. Implications for infarct repair. J Cell Biol 149: 731–740

    Article  CAS  Google Scholar 

  18. Menasché P et al. (2003) Autologous skeletal myoblast transplantation for severe postinfarction left ventricular dysfunction. J Am Coll Cadiol 41: 1078–1083

    Article  Google Scholar 

  19. Dib N et al. (2003) Two year follow up of the safety and feasibility of autologous myoblast transplantation in patients with ischemic cardiomyopathy: results from the United States experience [abstract]. Circulation 108 (Suppl IV): IV-623

    Google Scholar 

  20. Herreros J et al. (2003) Autologous intramyocardial injection of cultured skeletal muscle-derived stem cells in patients with non-acute myocardial infarction. Eur Heart J 24: 2012–2020

    Article  Google Scholar 

  21. Chachques JC et al. (2003) Autologous human serum for cell culture avoids the implantation of cardioverter-defibrillators in cellular cardiomyoplasty [abstract]. Circulation 108 (Suppl IV): IV-623

    Google Scholar 

  22. Pagani FD et al. (2003) Autologous skeletal myoblasts transplanted to ischemia-damaged myocardium in humans. Histological analysis of cell survival and differentiation. J Am Coll Cardiol 41: 879–888

    Article  Google Scholar 

  23. Haider HK et al. (2004) Myoblast transplantation for cardiac repair: a clinical perspective. Mol Ther 9: 14–23

    Article  CAS  Google Scholar 

  24. Ince H et al. (2004) Transcatheter transplantation of autologous skeletal myoblasts in postinfarction patients with severe left ventricular dysfunction. J Endovasc Ther 11: 695–704

    Article  Google Scholar 

Download references

Acknowledgements

The research was supported by a governmental grant from Komitet Badan Naukowych (State Committee for Scientific Research) and by an unrestricted research grant from the Polpharma Foundation.

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Authors and Affiliations

  1. Professor of Cardiology, Poznań University School of Medical Sciences, Poznań, Poland

    Tomasz Siminiak

  2. Research Fellow at the Poznań University School of Medical Sciences, Poznań, Poland

    Pawel Burchardt

  3. Professor of Genetics at the Institute of Human Genetics, Polish Academy of Sciences, Poznań, Poland

    Maciej Kurpisz

Authors
  1. Tomasz Siminiak
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  2. Pawel Burchardt
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  3. Maciej Kurpisz
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Correspondence to Tomasz Siminiak.

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The authors declare no competing financial interests.

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Siminiak, T., Burchardt, P. & Kurpisz, M. Postinfarction heart failure: surgical and trans-coronary-venous transplantation of autologous myoblasts. Nat Rev Cardiol 3 (Suppl 1), S46–S51 (2006). https://doi.org/10.1038/ncpcardio0403

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