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GPIs on a chip

Synthetic organic chemistry of complex natural products and their substructures provides challenges for the chemist and invaluable tools for the biologist. The production of a 'GPI chip', a device for simultaneously measuring and characterizing antibody responses to GPI structures, is applied to dissect malaria-induced antibody responses.

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Figure 1: Probing anti-GPI antibody levels and specificity.

Katie Ris-Vicari

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Ferguson, M. GPIs on a chip. Nat Chem Biol 4, 223–224 (2008). https://doi.org/10.1038/nchembio0408-223

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