Homo- and heterodimerization of G protein–coupled receptors (GPCRs) have been described for numerous receptors, but their functional role has remained elusive. With a new spectroscopic assay based on protein fragment complementation, GPCR heterodimerization was demonstrated to contribute to a phenomenon called 'functional selectivity'.
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References
Smith, N.J. & Milligan, G. Pharmacol. Rev. 62, 701–725 (2010).
Kniazeff, J., Prezeau, L., Rondard, P., Pin, J.P. & Goudet, C. Pharmacol. Ther. 130, 9–25 (2011).
Whorton, M.R. et al. Proc. Natl. Acad. Sci. USA 104, 7682–7687 (2007).
Albizu, L. et al. Nat. Chem. Biol. 6, 587–594 (2010).
Vilardaga, J.P. et al. Nat. Chem. Biol. 4, 126–131 (2008).
Han, Y., Moreira, I.S., Urizar, E., Weinstein, H. & Javitch, J.A. Nat. Chem. Biol. 5, 688–695 (2009).
Gilchrist, A. Trends Pharmacol. Sci. 28, 431–437 (2007).
Urizar, E. et al. Nat. Chem. Biol. 7, 624–630 (2011).
Smith, N.J., Bennett, K.A. & Milligan, G. Mol. Cell. Endocrinol. 331, 241–247 (2011).
Galés, C. et al. Nat. Struct. Mol. Biol. 13, 778–786 (2006).
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Piehler, J. Caught in a spectroscopic trap. Nat Chem Biol 7, 578–579 (2011). https://doi.org/10.1038/nchembio.641
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DOI: https://doi.org/10.1038/nchembio.641
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