STIM proteins are ubiquitous endoplasmic reticulum Ca2+ sensors that rapidly translocate to couple with 'store-operated' Orai Ca2+ channels when luminal Ca2+ levels are low. STIM1 also senses heat changes, which trigger a similar translocation and prime STIM1 to activate Orai, suggesting that STIM1 functions as a sensor of multiple stress signals.
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D.L.G. is partly supported by Novartis Institutes for Biomedical Research.
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Mancarella, S., Wang, Y. & Gill, D. STIM1 senses both Ca2+ and heat. Nat Chem Biol 7, 344–345 (2011). https://doi.org/10.1038/nchembio.587
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DOI: https://doi.org/10.1038/nchembio.587
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