Compound 4
3-bromo-N-(4-methoxy-[1,1'-biphenyl]-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
From: Overcoming resistance to HER2 inhibitors through state-specific kinase binding
Synthetic procedure: See article for the definitive version of this procedure and for full experimental details.
A microwave tube containing 19.3 mg of 5-phenyl-o-anisidine (0.097 mmol), 25.1 mg of 3-bromo-4-chloro-1H-pyrazolo[3,4-d]pyrimidine (0.11 mmol), 9.2 µL of glacial acetic acid (0.16 mmol) and 1 mL of n-butanol with a stir bar was capped and heated to 130°C for 15 min in a microwave reactor. The reaction was cooled and concentrated by rotary evaporation. The residue was recrystallized in ethanol to give 30.7 mg of crude 4 as a white solid.
- PubChemID:
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316894707
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