A recent study reveals a new cellular pathway that clears the endoplasmic reticulum of misfolded, GPI-anchored proteins at the onset of endoplasmic reticulum (ER) stress. This mechanism, termed rapid ER stress–induced export, represents a nontranscriptional response to mitigate acute ER stress.
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Noack, J., Molinari, M. RESETting proteostasis. Nat Chem Biol 10, 881–882 (2014). https://doi.org/10.1038/nchembio.1652
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DOI: https://doi.org/10.1038/nchembio.1652