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Antimicrobial mechanisms

A sponge against fungal infections

Nature Chemical Biology volume 10, pages 411–412 (2014)Cite this article

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The finding that the antifungal activity of amphotericin B is primarily due to its ability to extract ergosterol from fungal membranes suggests a new rationale for drug design, which should lead to advanced treatments, particularly for invasive fungal infections.

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Figure 1: The antifungal mode of action of AmB.

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  1. Biophysics Division, Karl Lohner is in the Institute of Molecular Biosciences, University of Graz, Graz, Austria.,

    Karl Lohner

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  1. Karl Lohner
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Correspondence to Karl Lohner.

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The author declares no competing financial interests.

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Lohner, K. A sponge against fungal infections. Nat Chem Biol 10, 411–412 (2014). https://doi.org/10.1038/nchembio.1518

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