NAD+-dependent deacetylases of the sirtuin family have long been implicated in lifespan regulation, and the significance and molecular mechanism (or mechanisms) of this effect have engendered spirited debate. Two articles now spotlight the catabolism of NAD+ itself as a mediator of lifespan regulation.
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References
Guarente, L. & Picard, F. Cell 120, 473–482 (2005).
Nogueiras, R. et al. Physiol. Rev. 92, 1479–1514 (2012).
Burnett, C. et al. Nature 477, 482–485 (2011).
Chang, H.C. & Guarente, L. Cell 153, 1448–1460 (2013).
Laurent, G. et al. Mol. Cell 50, 686–698 (2013).
Csibi, A. et al. Cell 153, 840–854 (2013).
Jeong, S.M. et al. Cancer Cell 23, 450–463 (2013).
Mao, Z. et al. Proc. Natl. Acad. Sci. USA 109, 11800–11805 (2012).
Mouchiroud, L. et al. Cell 154, 430–441 (2013).
Schmeisser et al. Nat. Chem. Biol. 9, 693–700 (2013).
Fukushima, T. et al. J. Neurosci. Res. 42, 385–390 (1995).
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Jasper, H. Longevity focuses on NAD+. Nat Chem Biol 9, 666–667 (2013). https://doi.org/10.1038/nchembio.1369
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DOI: https://doi.org/10.1038/nchembio.1369
