Compared with most intracellular vesicles, the autophagosome is formed by an unusual event of vesicle budding involving an elusive sequence of membrane expansions that ends with a double membrane vesicle. It is now shown that actin polymerization inside the forming autophagosome is a driving force for the expansion and assembly of a functional autophagosome.
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Holland, P., Simonsen, A. Actin shapes the autophagosome. Nat Cell Biol 17, 1094–1096 (2015). https://doi.org/10.1038/ncb3224
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DOI: https://doi.org/10.1038/ncb3224
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