The transcription factor p73, a close relative of p53, has complex yet poorly understood roles in tumorigenesis. TAp73, a p73 variant, has now been shown to promote cancer cell proliferation by regulating glucose metabolism to control cellular biosynthetic pathways and antioxidant capacity.
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Regulation of the pentose phosphate pathway in cancer
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Fets, L., Anastasiou, D. p73 keeps metabolic control in the family. Nat Cell Biol 15, 891–893 (2013). https://doi.org/10.1038/ncb2810
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DOI: https://doi.org/10.1038/ncb2810
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Regulation of the pentose phosphate pathway in cancer
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