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A GTPase switch maintains CENP-A at centromeric chromatin

Nature Cell Biology volume 12, pages 1128–1130 (2010)Cite this article

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The histone H3 variant CENP-A defines centromeric chromatin, but it has been unclear how CENP-A is stably maintained at centromeres. It has now been shown that the CENP-A licensing factor HsKNL2 and the small GTPases activating protein MgcRacGAP cooperate to promote the stability of newly loaded CENP-A at centromeres.

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Figure 1: Pathway for incorporation of new CENP-A.

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Authors and Affiliations

  1. Lisa Prendergast and Kevin F. Sullivan are in the Centre for Chromosome Biology, School of Natural Sciences, National University of Ireland, Galway, Galway, Ireland. kevin.sullivan@nuigalway.ie,

    Lisa Prendergast & Kevin F. Sullivan

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  1. Lisa Prendergast
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  2. Kevin F. Sullivan
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The authors declare no competing financial interests.

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Prendergast, L., Sullivan, K. A GTPase switch maintains CENP-A at centromeric chromatin. Nat Cell Biol 12, 1128–1130 (2010). https://doi.org/10.1038/ncb1210-1128

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