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A new checkpoint takes shape

Cell duplication requires the coordination of nuclear division with diverse cellular morphogenesis events, such as cell wall growth. A novel checkpoint has been identified in yeast that coordinates these two events. Unexpectedly, the dynein-activating dynactin complex, but not dynein itself, is an essential component of this checkpoint mechanism.

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Figure 1: Two checkpoint pathways monitor aspects of S. cerevisiae bud growth.

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Hoyt, M. A new checkpoint takes shape. Nat Cell Biol 6, 801–803 (2004). https://doi.org/10.1038/ncb0904-801

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