In Caernorhabditis elegans, homologue pairing is mediated by specialized regions near one end of each chromosome in conjunction with zinc finger (ZnF)-bearing proteins. Families of repeated sequences that are enriched within these regions have now been identified. By recruiting their cognate ZnF-bearing proteins, these regions promote pairing and synapsis.
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References
Phillips el al. Nature Cell Biol. 11, 934–942 (2009).
McKim, K. S., Peters, K. & Rose, A. M. Genetics 134, 749–768 (1993).
Villeneuve, A. M. Genetics 136, 887–902 (1994).
Zetka, M. Genome Dynamics 5, 43–55 (2009).
MacQueen, A. J., Colaiacovo, M. P., McDonald, K. & Villeneuve, A. M . Genes Dev. 16, 2428–2442 (2002).
MacQueen, A. J. et al. Cell 123, 1037–1050 (2005).
Phillips, C. M. & Dernburg, A. F. Dev. Cell 11, 817–829 (2006).
Phillips, C. M. et al. Cell 123, 1051–1063 (2005).
Dresser, M. E. PLoS Genet. 4, e1000210 (2008).
Tomita, K. & Cooper, J. P. Cell 125, 19–20 (2006).
Xu, D., Rener, X., Yu, J., Xu, T. & Han, M. Dev. Cell 12, 863–872 (2007).
McKee, B. D. Genome Dynamics 5, 56–58 (2009).
Dernburg, A.F., Sedat, J. W. & Hawley, R. S. Cell 86, 135–146 (1996).
Haber, J. E., Thorburn, P. C. & Rogers, D. Genetics 106, 185–205 (1984).
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Hawley, R., Gilliland, W. Homologue pairing: getting it right. Nat Cell Biol 11, 917–918 (2009). https://doi.org/10.1038/ncb0809-917
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DOI: https://doi.org/10.1038/ncb0809-917