The small GTPases Arl3p and Arl1p function sequentially to recruit diverse effector proteins to the Golgi apparatus. Similarly to ARF proteins, Arl1p is targeted to membranes by myristoylation. Arl3p, however, is not myristoylated. Recent work demonstrates that Arl3p, and its mammalian orthologue ARFRP1, are targeted to membranes by amino-terminal acetylation, which facilitates recognition by the membrane receptor Sys1p/hSys1.
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References
Moss, J. & Vaughan, M. J. Biol. Chem. 270, 12327–12330 (1995).
Donaldson, J.G., Radhakrishna, H. & Peters, P.J. Cold Spring Harb. Symp. Quant. Biol. 60, 229–234 (1995).
Beraud-Dufour, S., Paris, S., Chabre, M. & Antonny, B. J. Biol. Chem. 274, 37629–37636 (1999).
Pasqualato, S., Renault, L. & Cherfils, J. EMBO Rep. 3, 1035–1041 (2002).
Behnia, R., Panic, B., Whyte, J.R. & Munro, S. Nature Cell Biol. 6, 405–413 (2004).
Setty, S.R., Strochlic, T.I., Tong, A.H., Boone, C. & Burd, C.G. Nature Cell Biol. 6, 414–419 (2004).
Nie, Z., Hirsch, D.S. & Randazzo, P.A. Curr. Opin. Cell Biol. 15, 396–404 (2003).
Bonifacino, J.S. & Lippincott-Schwartz, J. Nature Rev. Mol. Cell Biol. 4, 409–414 (2003).
Lu, L., Horstmann, H., Ng, C. & Hong, W. J. Cell Sci. 114, 4543–4555 (2001).
Van Valkenburgh, H., Shern, J.F., Sharer, J.D., Zhu, X. & Kahn, R.A. J. Biol. Chem. 276, 22826–22837 (2001).
Barr, F.A. & Short, B. Curr. Opin. Cell Biol. 15, 405–413 (2003).
Panic, B., Whyte, J.R. & Munro, S. Curr. Biol. 13, 405–410 (2003).
Setty, S.R., Shin, M.E., Yoshino, A., Marks, M.S. & Burd, C.G. Curr. Biol. 13, 401–404 (2003).
Polevoda, B. & Sherman, F. Biochem. Biophys. Res. Commun. 308, 1–11 (2003).
Gommel, D.U. et al. EMBO J. 20, 6751–6760 (2001).
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Jackson, C. N-terminal acetylation targets GTPases to membranes. Nat Cell Biol 6, 379–380 (2004). https://doi.org/10.1038/ncb0504-379
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DOI: https://doi.org/10.1038/ncb0504-379
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Composition and biological significance of the human Nα-terminal acetyltransferases
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