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Cdc48–Ufd2–Rad23: the road less ubiquitinated?

Nature Cell Biology volume 7, pages 207–209 (2005)Cite this article

Targeting substrates to the proteasome is generally thought to depend on long polyubiquitin chains that form on the substrate. Recent work has led to the provocative proposal that some substrates may be targeted to the proteasome through smaller chains that contain only four to six ubiquitin molecules.

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Figure 1: Two roads to the proteasome? In the two-route pathway (top pathway) proposed by Richly et al.1, a substrate is first mono- or di-ubiquitinated by E1, E2 and E3.

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Authors and Affiliations

  1. Division of Biology, University of California San Diego, 2111 Pacific Hall 0347, 9500 Gilman Drive, La Jolla, 92093-0347, CA, USA

    Omar A. Bazirgan & Randolph Y. Hampton

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  1. Omar A. Bazirgan
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  2. Randolph Y. Hampton
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Bazirgan, O., Hampton, R. Cdc48–Ufd2–Rad23: the road less ubiquitinated?. Nat Cell Biol 7, 207–209 (2005). https://doi.org/10.1038/ncb0305-207

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